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KMID : 0043320030260110925
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Archives of Pharmacal Research
2003 Volume.26 No. 11 p.925 ~ p.928
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Cytotoxic Effects of Sesquiterpene Lactones from the Flowers of Hemisteptia Iyrata B.
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Ha Tae-Joung
Jang Dae-Sik
Lee Jong-Rok
Lee Kyung-Dong
Lee Jun
Hwang Seon-Woo
Jung Hwa-Jin
Nam Sang-Hae
Park Ki-Hoon
Yang Min-Suk
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Abstract
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Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia Iyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.
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KEYWORD
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Hemisteptia Iyrata Bunge, Sesquiterpene lactone, Aguerin B, Cynaropicrin, Deacylcynaropicrin, Cytotoxic activity
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